The shape of a dome house makes it difficult to conform to code requirements for placement of sewer vents and chimneys. Off-the-shelf building materials (e.g., plywood, strand board) normally come in rectangular shapes; there can be considerably more scrap, left from cutting rectangles down to triangles, than with a conventional building approach, thus driving costs up. Fire escapes are problematic; codes require them for larger structures, and they are expensive. Windows conforming to code can cost anywhere from five to fifteen times as much as windows in conventional houses. Professional electrical wiring costs more because of increased labor time. However, even owner-wired situations are costly, because more of certain materials are required for dome construction.

Air stratification and moisture distribution within a dome are unusual, and these conditions tend to quickly degrade wooden framing or interior paneling. Privacy is difficult to guarantee because a dome is difficult to partition satisfactorily. Sounds, smells, and even reflected light tend to be conveyed through the entire structure.

As with any sloping shape, the dome produces wall areas that can be difficult to use and leaves some peripheral floor area with restricted use due to lack of headroom. This can leave a volume that may require heating – representing a cost in energy – but that cannot be lived in. Circular plan shapes lack the simple modularity provided by rectangles. Furnishers and fitters usually design with flat surfaces in mind, and so placing a standard sofa (for example) results in a half-moon behind the sofa being wasted. This is best overcome by purpose-built fittings, though it adds to cost.

Dome builders using cut-board sheathing materials find it hard to seal domes against rain, because of their many seams; as well, these seams may be stressed because ordinary solar heat flexes the entire structure each day as the sun moves across the sky.

The most effective waterproofing method with a wooden dome is to shingle the dome. One-piece reinforced concrete or plastic domes are also in use, and some domes have been constructed from plastic or waxed cardboard triangles that are overlapped in such a way as to shed water. Buckminster Fuller's former student J. Baldwinstates that there is no reason for a properly designed, well-constructed dome to leak, and that some designs cannot leak (Bucky Works: Buckminster Fuller's Ideas for Today). However, Lloyd Kahn, after writing two books on the subject (Domebook 1 and Domebook 2), became disillusioned with domes. He calls domes "smart but not wise",^[2] and has collected many of the criticisms given above.